A. Community surveys suggest that approximately 5% of adults have made a serious suicide attempt. B. Mental health conditions most strongly associated with fatal and nonfatal suicide attempts include depression, bipolar disorder, PTSD, and alcohol and/or drug abuse. C. Occasional reactivity to negative emotional stimuli that occurs at least once per week as a reaction to depression. D. Men with a substance use disorder are more likely to die of suicide than are women with a substance abuse disorder. E. Older men with substance use disorders are at greater risk for death by suicide than are younger persons.